Authored by the Simon group - Providing more effective and affordable health care

Laboratory Online is a series of educational and interactive modules offered by the Simon group. The purpose of the project is to enhance knowledge in drug-delivery technologies and underlying engineering principles. Within this user-friendly environment, practitioners and researchers can enter their own process parameter values in corresponding boxes (or use the default quantities provided). The findings of the simulation study are monitored in real-time by pressing the red-shaded button near the bottom of the page.

Cylindrical matrix device with a release area

L. Simon and J. Ospina

Drug transport through a cylindrical drug-delivery device with a circular release area is simulated. This interactive module focuses on the influences of design specifications (e.g., H/R) on the transport of medication and the effective time constant - an indication of how quickly the profile approaches an equilibrim value (Fig. 1). In this example, the release area and the device are of equal diameters[1, 2].




Fig. 1. Cylindrical Drug-Delivery Device with a Release Area.

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ENTER DATA HERE

H/R :

Sh :

Normalized cumulative amount of drug released

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References

[1] Tojo K. (1984). Prolonged drug release from a simple cylindrical device with a small hole, Chem. Eng. Commun., 30 ,311-322.

[2] Simon, L. and Ospina, J. (2013), Two-dimensional solution and analysis of a cylindrical matrix device with a circular release area, Chem. Eng. Commun., 200, 115-138.

Released 11/05/08. Recently modified 11/05/08.
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