Authored by the Simon group - Providing more effective and affordable health care

Laboratory Online is a series of educational and interactive modules offered by the Simon group. The purpose of the project
is to enhance knowledge in drug-delivery technologies and underlying engineering principles.

Within this user-friendly environment, practitioners and researchers can enter their own process parameter values in
corresponding boxes (or use the default quantities provided). The findings of the simulation study are monitored in real-time by pressing
the red-shaded button near the bottom of the page.

In Vitro Drug Release from Microspheres

Contribution by Kwang Seok Kim

This program simulates drug release from microspheres. The default parameters are taken from in vitro release tests of 5-fluorouracil-loaded microspheres. The drug is used in the treatment of several types of cancers, including colorectal cancer. Users can enter their own experimental data.

NO MATHEMATICAL OR PRIOR PROGRAMMNG KNOWLEDGE IS NECESSARY to use the module.

Please enter the experimental and preparation conditions for the drug-loaded microspheres in the the boxes provided below, (Default values are taken from [1].):

1. mg of drug and mg of polymer are dissolved in mL of solvent.

2. The solution in part 1. is emulsified into a heated liquid while the solvent is evaporated. Then, the liquid is removed and the microspheres are washed to clean the surfaces. Measurement show that the size of a microsphere is 痠 in diameter.

3. mg of microspheres are suspended in mL of medium(*).
* Insert a large value when the medium is replaced with a fresh solution at each sampling interval (e.g., use 100 mL instead of 1 mL)

Extra properties

Diffusion coefficient of drug: cm²/hr
Dissolution rate constant: mg/cm³hr
Solubility of drug in the medium: mg/cm³
Density of drug: mg/cm³
Density of polymer: mg/cm³

Enter your experimental results below (optional)

Time [hr]
Cumulative released fraction

Variable "$$dia" cannot be interpreted since it has not been assigned a\
 
>   value.

REMARKS:
The initial porosity of a microsphere is gpol gdrug 1. - -------- - -------- dp vsolv S0 vsolv.
A total Round[NT] microspheres are present in the formulation.

References

[1] Moritero T, Oguro Y, Honda Y, Wada R, Hyon S-H, Ikada Y. (1991), Microspheres of biodegradable polymers as a drug-delivery system in the vitreous, Investigative Ophthalmology & Visual Science, 32, 1785-1790.

Released 04/09/10. Recently modified 04/09/10.
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