Authored by the Simon group - Providing more effective and affordable health care

Laboratory Online is a series of educational and interactive modules offered by the Simon group. The purpose of the project is to enhance knowledge in drug-delivery technologies and underlying engineering principles. Within this user-friendly environment, practitioners and researchers can enter their own process parameter values in corresponding boxes (or use the default quantities provided). The findings of the simulation study are monitored in real-time by pressing the red-shaded button near the bottom of the page.

Two-Dimensional Drug Transport Across the Skin

L. Simon and J. Ospina

This program estimates the delivery rate, the effective time constant and the cumulative amount of drug permeated through the skin. The dimensions of the patch and the dermal layer are given in Fig. 1. During treatment, the drug concentration in the vehicle remains virtually constant. The medication is eliminated at the skin-capillary interface and absorbed into the systemic circulation [1].




Fig. 1. Drug transport across the skin.

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ENTER DATA HERE

D : cm²/h

l_s : cm

C_b : µg/mL

K_cl : cm/h

h_c : cm

h_d : cm

h_u : cm

Cumulative amount of drug released per unit area (µg/cm²)



Drug delivery rate (µg/cm²h)

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References

[1] Simon, L. and Ospina, J. (2013), Two-dimensional transport analysis of transdermal drug absorption with a non-perfect sink boundary condition at the skin-capillary interface, Mathematical Biosciences, in press.

Released 11/05/08. Recently modified 11/05/08.
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