Authored by the
Providing more effective and affordable health care
is a series of educational and interactive modules
offered by the Simon group.
The purpose of the project
enhance knowledge in drug-delivery technologies and underlying engineering principles.
Within this user-friendly environment,
practitioners and researchers can enter their own process parameter values
corresponding boxes (or use the default quantities provided). The findings of the simulation study are
monitored in real-time by pressing
near the bottom of the page.
Optimal dosage regimen using one-compartment models
An optimal multiple IV bolus dosing regimen is computed to maintain the plasma concentration of the drug within a therapeutic range (i.e.,
). The apparent volume of distribution (
) and elimination rate constant (
) are also specified by the user.
Fig. 1. One-compartment model
The data are entered here
The dosing interval Τ (h):
The loading dose LD (mg):
The maintenance dose D (mg):
The number of doses required to reach steady-state:
The plasma drug concentration:
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