Authored by the Simon group - Providing more effective and affordable health care

Laboratory Online is a series of educational and interactive modules offered by the Simon group. The purpose of the project is to enhance knowledge in drug-delivery technologies and underlying engineering principles. Within this user-friendly environment, practitioners and researchers can enter their own process parameter values in corresponding boxes (or use the default quantities provided). The findings of the simulation study are monitored in real-time by pressing the red-shaded button near the bottom of the page.

Iontophoretic transdermal drug delivery

This program simulates the ionic transport of drug through the skin assuming that there is negligible convective flow, no binding in the stratum corneum and no drug metabolism in the viable skin (Fig. 1): D is the effective diffusion coefficient of the drug in the membrane, C is the concentration in the skin, h is the skin thickness, t represents the time and x is the spatial variable. A partition coefficient (K) relates the drug concentration at the membrane surface to the concentration in the donor chamber. The parameter ν is defined by zFE/RT where z is the charge number of the drug, E is the potential drop across the membrane, R is the gas constant, F is the Faraday constant and T is the absolute temperature [1].




Fig. 1. Iontophoretic Drug transport across a membrane.

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ENTER DATA HERE

D : cm²/h

h : cm

C_s : µg/mL

ν :

Cumulative amount of drug released per unit area (µg/cm²)



Diffusion flux into the receiver compartment (µg/cm²h)

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References

[1] Simon, L., Weltner, A.W., Wang, Y. and Michniak, B. (2006), A parametric study of iontophoretic transdermal drug-delivery systems, Journal of Membrane Science, 278, 124-132.

Released 11/05/08. Recently modified 11/05/08.
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