Authored by the Simon group - Providing more effective and affordable health care

Laboratory Online is a series of educational and interactive modules offered by the Simon group. The purpose of the project is to enhance knowledge in drug-delivery technologies and underlying engineering principles. Within this user-friendly environment, practitioners and researchers can enter their own process parameter values in corresponding boxes (or use the default quantities provided). The findings of the simulation study are monitored in real-time by pressing the red-shaded button near the bottom of the page.

Two-compartment Pharmacokinetic model

Kwangseok Kim

This program provides time-varying concentration profiles of a drug in the plasma (C1) and the tissue compartments (C2). The input dosage regimen consists of 3 boluses followed by a constant rate infusion of the medicament. A two-compartment pharmacokinetic model, with Michaelis-Menten elimination kinetics, was used to simulate the process (Fig. 1). Orthogonal collocation on finite elements techniques were applied to solve the problem [1].



Fig. 1. The two-compartment pharmacokinetic model.

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ENTER DATA HERE

Set point : ug/mL

1st Dosage : Time hr, Size ug/mL

2nd Dosage : Time hr, Size ug/mL

3rd Dosage : Time hr, Size ug/mL

Distribution kinetics :
C1 to C2 /hr, C2 to C1 /hr

Elimination kinetics:
Vm ug/mL/hr, Km ug/mL

Time(hr)-dependent concentration profiles (ug/ml)

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References

[1] Kim, K.S. and Simon, L. (2009), Optimal intravenous bolus-infusion drug dosage regimen based on two-compartment pharmacokinetic models, Computers & Chemical Engineering, 33, 1212-1219.

Released 11/05/08. Recently modified 11/05/08.
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